First-pass elimination takes place when a drug is metabolised between its site of
administration and the site of sampling for measurement of drug concentration. Clinically …

The significance of studying the kinetics of drug partitioning into red blood cells (RBCsb) in
animals and humans is not fully appreciated, although the importance of routine …

This review discusses the pharmacokinetics and pharmacodynamics of glyceryl trinitrate
(nitroglycerin; GTN) pertinent to clinical medicine. The pharmacokinetics of GTN associated …

Interventional Pericardiology gives a unique and comprehensive view on an often neglected
but clinically very important part of cardiovascular disease: The pericardium and the …

The expanding role of intravenous nitroglycerin (GTN) in the management of critically ill
hospitalized patients demands a clear knowledge of its pharmacodynamics and kinetics in …

The purpose of this investigation was to examine the pharmacokinetics of nitroglycerin in
normal volunteers after intravenous drug administration. Eight subjects (including one …

In a study of GTN absorption during exercise and high ambient temperature, 12 healthy
volunteers carried 10 mg glyceryl trinitrate (GTN, nitroglycerin) transdermal patches for 6 …

The effect of 2 per cent nitroglycerin paste applied to the penile shaft of impotent subjects
was evaluated in a placebo controlled double-blind study under laboratory conditions. After …

Contrary to the belief that the RBC is not metabolically active towards pharmacologically
active endogenous and exogenous substances, it is evident that the RBC contains moderate …

Synopsis: The recently introduced preparation of intravenous glyceryl trinitrate 1
(nitroglycerin) provides a rapid steady therapeutic blood concentration of nitrates during …