Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Proton MRS (1H MRS) provides noninvasive, quantitative metabolite profiles of tissue and
has been shown to aid the clinical management of several brain diseases. Although most …

Metabolomics is an emerging'omics' science involving the comprehensive characterization
of metabolites and metabolism in biological systems. Recent advances in metabolomics …

A large body of published work shows that proton (hydrogen 1 [1H]) magnetic resonance
(MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality …

Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

The current knowledge of the normal biochemistry of compounds that give rise to
resonances in human brain proton magnetic resonance spectra measureable at readily …

Proton MR spectra of the brain, especially those measured at short and intermediate echo
times, contain signals from mobile macromolecules (MM). A description of the main MM is …

Cramér Rao Lower Bounds (CRLB) have become the standard for expression of
uncertainties in quantitative MR spectroscopy. If properly interpreted as a lower threshold of …

Conclusion MRS has become established as a robust and powerful tool for the investigation
of the inhibitory neurotransmitter GABA. This is a significant success, given the significant …

Hyperammonemia can be caused by various acquired or inherited disorders such as urea
cycle defects. The brain is much more susceptible to the deleterious effects of ammonium in …