Abstract Purpose This Position Paper aims to review and discuss the available data on
therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill …

Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …

Background: To promote model-informed precision dosing (MIPD) for vancomycin (VCM),
we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical …

Model-informed precision dosing (MIPD) software tools are used to optimize dosage
regimens in individual patients, aiming to achieve drug exposure targets associated with …

Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …

Many important drugs exhibit substantial variability in pharmacokinetics and
pharmacodynamics leading to a loss of the desired clinical outcomes or significant adverse …

Background and objective External evaluation is an important issue in the population
pharmacokinetic analysis of antibiotics. The purpose of this review was to summarize the …

Abstract Model‐informed precision dosing (MIPD) approaches typically apply maximum a
posteriori (MAP) Bayesian estimation to determine individual pharmacokinetic (PK) …

Background Precision dosing programs are promising tools for optimising antimicrobial
dosing. Selecting the ideal program for local application may be challenging due to the large …

Individualization of vancomycin dosing based on therapeutic drug monitoring (TDM) data is
known to improve patient outcomes compared with fixed or empirical dosing strategies …