Importance Acute respiratory distress syndrome (ARDS) is a life-threatening form of
respiratory failure that affects approximately 200 000 patients each year in the United States …

Sepsis is defined as organ dysfunction resulting from the host's deleterious response to
infection. One of the most common organs affected is the kidneys, resulting in sepsis …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Importance Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019
(COVID-19) is associated with substantial mortality and use of health care resources …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Background The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting …

Rationale: Mortality in acute respiratory distress syndrome (ARDS) has decreased after the
adoption of lung-protective strategies. Lower Vt, lower driving pressure (ΔP), lower …

Importance Adjusting positive end-expiratory pressure (PEEP) to offset pleural pressure
might attenuate lung injury and improve patient outcomes in acute respiratory distress …

Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

Background: This document updates previously published Clinical Practice Guidelines for
the management of patients with acute respiratory distress syndrome (ARDS), incorporating …