Amorphous solid dispersion (ASD) is a promising strategy to enhance solubility and
bioavailability of poorly water-soluble drugs. Due to higher free energy of ASD …

High drug load amorphous solid dispersions (ASDs) have been a challenge to formulate
partially because drug release is inhibited at high drug loads. The maximum drug load prior …

An ideal dissolution test for amorphous solid dispersions (ASDs) should reflect
physicochemical, physiological, and hydrodynamic conditions which accurately represent in …

The in-situ formation of nanoparticles from polymer-based solid medicines, although
previously described, has been overlooked despite its potential to interfere with oral drug …

Polymers play an important role in amorphous solid dispersions (ASDs), enhancing stability
in the solid state and maintaining supersaturation in aqueous solutions of intrinsically low …

Nanodroplet formation is important to achieve supersaturation of active pharmaceutical
ingredients (APIs) in an amorphous solid dispersion. The aim of the current study was to …

Drug-rich droplets formed through liquid–liquid phase separation (LLPS) have the potential
to enhance the oral absorption of drugs. This can be attributed to the diffusion of these …

Cocrystallization and coamorphization are similar yet independent approaches toward
modifying various pharmaceutically relevant properties of modern drug compounds, in …

It is now recognized that a number of excipients previously considered to be “inert” have the
capacity to alter drug oral bioavailability through a range of in vivo effects. The various …

Enzalutamide (ENZ), marketed under the brand name Xtandi® as a soft capsule, is an
androgen receptor signaling inhibitor drug actively used in clinical settings for treating …