Development of polymeric nanoparticles for blood–brain barrier transfer—strategies and challenges

W Zhang, A Mehta, Z Tong, L Esser… - Advanced …, 2021 - Wiley Online Library
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …

In vitro models of the blood–brain barrier: an overview of commonly used brain endothelial cell culture models and guidelines for their use

HC Helms, NJ Abbott, M Burek… - Journal of Cerebral …, 2016 - journals.sagepub.com
The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …

Surface-modified nanocarriers for nose-to-brain delivery: from bioadhesion to targeting

F Sonvico, A Clementino, F Buttini, G Colombo… - Pharmaceutics, 2018 - mdpi.com
In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating
applications, directly targeting the central nervous system, bypassing the blood brain barrier …

Nanocarriers' entry into the cell: relevance to drug delivery

H Hillaireau, P Couvreur - Cellular and molecular life sciences, 2009 - Springer
Nanocarriers offer unique possibilities to overcome cellular barriers in order to improve the
delivery of various drugs and drug candidates, including the promising therapeutic …

The present and future of nanotechnology in human health care

SK Sahoo, S Parveen, JJ Panda - Nanomedicine in Cancer, 2017 - api.taylorfrancis.com
Nanotechnology can be defined as the science and engineering involved in the design,
synthesis, characterization and application of materials and devices whose smallest …

Nano carriers for drug transport across the blood–brain barrier

X Li, J Tsibouklis, T Weng, B Zhang, G Yin… - Journal of drug …, 2017 - Taylor & Francis
Effective therapy lies in achieving a therapeutic amount of drug to the proper site in the body
and then maintaining the desired drug concentration for a sufficient time interval to be …

Bioengineered protein-based nanocage for drug delivery

EJ Lee, NK Lee, IS Kim - Advanced drug delivery reviews, 2016 - Elsevier
Nature, in its wonders, presents and assembles the most intricate and delicate protein
structures and this remarkable phenomenon occurs in all kingdom and phyla of life. Of these …

Prospects and applications of nanobiotechnology: a medical perspective

M Fakruddin, Z Hossain, H Afroz - Journal of nanobiotechnology, 2012 - Springer
Background Nanobiotechnology is the application of nanotechnology in biological fields.
Nanotechnology is a multidisciplinary field that currently recruits approach, technology and …

Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review

J Bicker, G Alves, A Fortuna, A Falcão - European Journal of Pharmaceutics …, 2014 - Elsevier
During the research and development of new drugs directed at the central nervous system,
there is a considerable attrition rate caused by their hampered access to the brain by the …

Neuroscience nanotechnology: progress, opportunities and challenges

GA Silva - Nature reviews neuroscience, 2006 - nature.com
Nanotechnologies exploit materials and devices with a functional organization that has been
engineered at the nanometre scale. The application of nanotechnology in cell biology and …