Sigma receptor (σR) ligands have proven to be useful as cancer diagnostics and anticancer
therapeutics and their ligands have been developed as molecular probes in oncology …

Two problems that have hampered a receptor research are (i) a lack of high-affinity agents
and (ii) the recent identification of multiple populations of a receptors (ie, a\and< 72 sites) …

Publisher Summary This chapter discusses the debate that continues over whether σ sites
are true receptors or a membrane bound enzyme. Although σ receptors have been …

A lingering question in σ receptor ligand development is whether a nitrogen atom serves as
an important pharmacophoric element in binding affinity. To address this question, we have …

The proposed phenyl-A region of sigma (σ) receptors accommodates several structural
features. In this study we explored the possibility that appropriate structural features located …

The invention relates to methods for the treatment of central nervous system disorders,
neurological disorders, gas trointestinal disorders, drug abuse, angina, migraine, hyper …

Carbetapentane (1, 2-[2-(diethylamino) ethoxy] ethyl 1-phenyl-l-cyclopentanecarboxylate)
binds with high affinity to a sites and is a potent antitussive, anticonvulsant, and spasmolytic …

Sigma (sigma) receptors, once considered a type of opioid receptor, are now recognized as
representing a unique receptive entity and at least two different types of sigma receptors …

A comparative molecular field analysis (CoMFA) investigation was conducted on the binding
of 64 compounds to σ1 receptors. Although CoMFA accurately predicted the binding …

A sigma-1 receptor selective analogue of BD1008. a potential substitute for (+)-opioids in
sigma receptor binding assays - ScienceDirect Skip to main contentSkip to article Elsevier …