SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)

AD Proal, MB VanElzakker, S Aleman, K Bach… - Nature …, 2023 - nature.com
Millions of people are suffering from Long COVID or post-acute sequelae of COVID-19
(PASC). Several biological factors have emerged as potential drivers of PASC pathology …

Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis

IP Trougakos, E Terpos, H Alexopoulos… - Trends in Molecular …, 2022 - cell.com
Vaccination is a major tool for mitigating the coronavirus disease 2019 (COVID-19)
pandemic, and mRNA vaccines are central to the ongoing vaccination campaign that is …

Persistent circulating severe acute respiratory syndrome coronavirus 2 spike is associated with post-acute coronavirus disease 2019 sequelae

Z Swank, Y Senussi, Z Manickas-Hill… - Clinical Infectious …, 2023 - academic.oup.com
The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an
ongoing medical challenge. To identify biomarkers associated with PASC we analyzed …

[HTML][HTML] Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study

N Barda, N Dagan, C Cohen, MA Hernán, M Lipsitch… - The Lancet, 2021 - thelancet.com
Background Many countries are experiencing a resurgence of COVID-19, driven
predominantly by the delta (B. 1.617. 2) variant of SARS-CoV-2. In response, these countries …

COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection

WY Chi, YD Li, HC Huang, TEH Chan, SY Chow… - Journal of biomedical …, 2022 - Springer
Abstract Coronavirus Disease 2019 (COVID-19) has been the most severe public health
challenge in this century. Two years after its emergence, the rapid development and …

Circulating spike protein detected in post–COVID-19 mRNA vaccine myocarditis

LM Yonker, Z Swank, YC Bartsch, MD Burns, A Kane… - Circulation, 2023 - Am Heart Assoc
Background: Cases of adolescents and young adults developing myocarditis after
vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted …

SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals

K Sano, D Bhavsar, G Singh, D Floda… - Nature …, 2022 - nature.com
Immune responses at the respiratory mucosal interface are critical to prevent respiratory
infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) …

Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent …

S Sheikh-Mohamed, B Isho, GYC Chao, M Zuo… - Mucosal …, 2022 - nature.com
Although SARS-CoV-2 infects the upper respiratory tract, we know little about the amount,
type, and kinetics of antibodies (Ab) generated in the oral cavity in response to COVID-19 …

Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines

J Szebeni, G Storm, JY Ljubimova, M Castells… - Nature …, 2022 - nature.com
After over a billion of vaccinations with messenger RNA-lipid nanoparticle (mRNA-LNP)
based SARS-CoV-2 vaccines, anaphylaxis and other manifestations of hypersensitivity can …

Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …