Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …

A centrosome consists of two barrel-shaped centrioles embedded in a matrix of proteins
known as the pericentriolar material (PCM). The PCM serves as a platform for protein …

The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an
integral role in the regulation of a number of major signaling pathways whose deregulation …

To provide accurate biological hypotheses and elucidate global properties of cellular
networks, systematic identification of protein-protein interactions must meet high quality …

Autosomal recessive primary microcephaly (MCPH;“small head syndrome”) is a rare,
heterogeneous disease arising from the decreased production of neurons during brain …

Despite being essential for spatial cell division control, the mechanisms governing spindle
positioning remain incompletely understood. In the Caenorhabditis elegans one-cell stage …

Interactions between microtubules and the cell cortex play a critical role in positioning
organelles in a variety of biological contexts. Here we used Caenorhabditis elegans as a …

Background The ways in which cells set the size of intracellular structures is an important but
largely unsolved problem [1]. Early embryonic divisions pose special problems in this …

Many protein-protein interactions are mediated through independently folding modular
domains. Proteome-wide efforts to model protein-protein interaction or" interactome" …

Abstract Tap42/α4, a regulatory subunit of protein phosphatase 2A, is a downstream effector
of the target of rapamycin (TOR) protein kinase, which regulates cell growth in coordination …