SARS‐CoV‐2, the pandemic coronavirus: Molecular and structural insights

SB Kadam, GS Sukhramani, P Bishnoi… - Journal of basic …, 2021 - Wiley Online Library
The outbreak of a novel coronavirus associated with acute respiratory disease, called
COVID‐19, marked the introduction of the third spillover of an animal coronavirus (CoV) to …

RNA G-quadruplexes (rG4s): genomics and biological functions

K Lyu, EYC Chow, X Mou, TF Chan… - Nucleic acids …, 2021 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection

G Liu, W Du, X Sang, Q Tong, Y Wang, G Chen… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have
devastating consequences worldwide. Recently, great efforts have been made to identify …

Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19

Y Zhang, M Juhas, CK Kwok - Trends in Biotechnology, 2023 - cell.com
SARS-CoV-2, the causative agent of COVID-19, remains among the main causes of global
mortality. Although antigen/antibody-based immunoassays and neutralizing antibodies …

Unlocking G-quadruplexes as antiviral targets

A Abiri, M Lavigne, M Rezaei, S Nikzad, P Zare… - Pharmacological …, 2021 - ASPET
Guanine-rich DNA and RNA sequences can fold into noncanonical nucleic acid structures
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …

[HTML][HTML] Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19

R Li, K Wu, Y Li, X Liang, WKF Tse, L Yang… - Aging (albany …, 2020 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), an epidemic disease characterized by rapid infection and a high …

G-quadruplex targeting in the fight against viruses: An update

E Ruggiero, I Zanin, M Terreri, SN Richter - International journal of …, 2021 - mdpi.com
G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of
key cellular processes, such as transcription and replication. Since their discovery, G4s have …

G-quadruplex-binding proteins: promising targets for drug design

H Shu, R Zhang, K Xiao, J Yang, X Sun - Biomolecules, 2022 - mdpi.com
G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with
the potential to form G4s are abundant in regulatory regions of the genome including …

Affinity Sensors for the Diagnosis of COVID-19

M Drobysh, A Ramanaviciene, R Viter, A Ramanavicius - Micromachines, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) was proclaimed a global pandemic in March 2020 …

RNA G-quadruplex formed in SARS-CoV-2 used for COVID-19 treatment in animal models

G Qin, C Zhao, Y Liu, C Zhang, G Yang, J Yang… - Cell Discovery, 2022 - nature.com
The ongoing COVID-19 pandemic has continued to affect millions of lives worldwide,
leading to the urgent need for novel therapeutic strategies. G-quadruplexes (G4s) have …