Molecular insight in the multifunctional activities of Withaferin A
Herbal medicine which involves the use of plants for their medicinal value, dates as far back
as the origin of mankind and demonstrates an array of applications including cardiovascular …
as the origin of mankind and demonstrates an array of applications including cardiovascular …
C-terminal modulators of heat shock protein of 90 kDa (HSP90): State of development and modes of action
Cells constantly need to adopt to changing environmental conditions, maintaining
homeostasis and proteostasis. Heat shock proteins are a diverse class of molecular …
homeostasis and proteostasis. Heat shock proteins are a diverse class of molecular …
Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences
K Vaishnavi, N Saxena, N Shah, R Singh, K Manjunath… - 2012 - journals.plos.org
Background and Purpose Withanolides are naturally occurring chemical compounds. They
are secondary metabolites produced via oxidation of steroids and structurally consist of a …
are secondary metabolites produced via oxidation of steroids and structurally consist of a …
Hsp90: Friends, clients and natural foes
Hsp90, a homodimeric ATPase, is responsible for the correct folding of a number of newly
synthesized polypeptides in addition to the correct folding of denatured/misfolded client …
synthesized polypeptides in addition to the correct folding of denatured/misfolded client …
Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway
K Heyninck, L Sabbe, CS Chirumamilla… - Biochemical …, 2016 - Elsevier
Withaferin A (WA), a natural phytochemical derived from the plant Withania somnifera, is a
well-studied bioactive compound exerting a broad spectrum of health promoting effects. To …
well-studied bioactive compound exerting a broad spectrum of health promoting effects. To …
Computational evidence to inhibition of human acetyl cholinesterase by withanolide a for Alzheimer treatment
A Grover, A Shandilya, V Agrawal… - Journal of …, 2012 - Taylor & Francis
Abstract Alzheimer's disease (AD), a neurodegenerative disorder, is the most common
cause of dementia. So far only five drugs have been approved by US FDA that temporarily …
cause of dementia. So far only five drugs have been approved by US FDA that temporarily …
Ashwagandha derived withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activity
Cancer is largely marked by genetic instability. Specific inhibition of individual proteins or
signalling pathways that regulate genetic stability during cell division thus hold a great …
signalling pathways that regulate genetic stability during cell division thus hold a great …
[HTML][HTML] Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts
The molecular co-chaperone CDC37 is over-expressed in hepatocellular carcinoma (HCC)
cells, where it functions with HSP90 to regulate the activity of protein kinases in multiple …
cells, where it functions with HSP90 to regulate the activity of protein kinases in multiple …
Enhanced withanolide production by overexpression of squalene synthase in Withania somnifera
Withania somnifera commonly known as Ashwagandha, is held in high repute in traditional
Indian medicine, largely due to the presence of steroidal lactone phytocompounds …
Indian medicine, largely due to the presence of steroidal lactone phytocompounds …
Pharmacological and analytical aspects of withaferin A: A concise report of current scientific literature
K Patel, RB Singh, DK Patel - Asian Pacific Journal of Reproduction, 2013 - Elsevier
Withaferin A is an important phytoconstituents of Withania somnifera (W. Somnifera)
belonging to the category of withanolides, that are a group of naturally occurring C 28 …
belonging to the category of withanolides, that are a group of naturally occurring C 28 …