Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics
Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders
that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium …
that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium …
Clostridium difficile infection: epidemiology, diagnosis and understanding transmission
JSH Martin, TM Monaghan, MH Wilcox - … reviews Gastroenterology & …, 2016 - nature.com
Clostridium difficile infection (CDI) continues to affect patients in hospitals and communities
worldwide. The spectrum of clinical disease ranges from mild diarrhoea to toxic megacolon …
worldwide. The spectrum of clinical disease ranges from mild diarrhoea to toxic megacolon …
The EnteroBase user's guide, with case studies on Salmonella transmissions, Yersinia pestis phylogeny, and Escherichia core genomic diversity
EnteroBase is an integrated software environment that supports the identification of global
population structures within several bacterial genera that include pathogens. Here, we …
population structures within several bacterial genera that include pathogens. Here, we …
Dietary trehalose enhances virulence of epidemic Clostridium difficile
Clostridium difficile disease has recently increased to become a dominant nosocomial
pathogen in North America and Europe, although little is known about what has driven this …
pathogen in North America and Europe, although little is known about what has driven this …
Multilocus sequence typing of total-genome-sequenced bacteria
Accurate strain identification is essential for anyone working with bacteria. For many
species, multilocus sequence typing (MLST) is considered the “gold standard” of typing, but …
species, multilocus sequence typing (MLST) is considered the “gold standard” of typing, but …
Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing
Background It has been thought that Clostridium difficile infection is transmitted
predominantly within health care settings. However, endemic spread has hampered …
predominantly within health care settings. However, endemic spread has hampered …
Effects of control interventions on Clostridium difficile infection in England: an observational study
Summary Background The control of Clostridium difficile infections is an international clinical
challenge. The incidence of C difficile in England declined by roughly 80% after 2006 …
challenge. The incidence of C difficile in England declined by roughly 80% after 2006 …
Diagnosis of Clostridium difficile infection: an ongoing conundrum for clinicians and for clinical laboratories
BD Carey-Ann, KC Carroll - Clinical microbiology reviews, 2013 - Am Soc Microbiol
Clostridium difficile is a formidable nosocomial and community-acquired pathogen, causing
clinical presentations ranging from asymptomatic colonization to self-limiting diarrhea to …
clinical presentations ranging from asymptomatic colonization to self-limiting diarrhea to …
Diversity and evolution in the genome of Clostridium difficile
DR Knight, B Elliott, BJ Chang… - Clinical microbiology …, 2015 - Am Soc Microbiol
Clostridium difficile infection (CDI) is the leading cause of antimicrobial and health care-
associated diarrhea in humans, presenting a significant burden to global health care …
associated diarrhea in humans, presenting a significant burden to global health care …
Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011
Farm animals are a potential reservoir for human Clostridium difficile infection (CDI),
particularly PCR ribotype 078 which is frequently found in animals and humans. Here, whole …
particularly PCR ribotype 078 which is frequently found in animals and humans. Here, whole …