The actin cytoskeleton as an active adaptive material

S Banerjee, ML Gardel… - Annual review of …, 2020 - annualreviews.org
Actin is the main protein used by biological cells to adapt their structure and mechanics to
their needs. Cellular adaptation is made possible by molecular processes that strongly …

F-actin architecture determines constraints on myosin thick filament motion

CG Muresan, ZG Sun, V Yadav, AP Tabatabai… - Nature …, 2022 - nature.com
Active stresses are generated and transmitted throughout diverse F-actin architectures
within the cell cytoskeleton, and drive essential behaviors of the cell, from cell division to …

Inferring entropy production from short experiments

SK Manikandan, D Gupta, S Krishnamurthy - Physical review letters, 2020 - APS
We provide a strategy for the exact inference of the average as well as the fluctuations of the
entropy production in nonequilibrium systems in the steady state, from the measurements of …

Estimating entropy production by machine learning of short-time fluctuating currents

S Otsubo, S Ito, A Dechant, T Sagawa - Physical Review E, 2020 - APS
Thermodynamic uncertainty relations (TURs) are the inequalities which give lower bounds
on the entropy production rate using only the mean and the variance of fluctuating currents …

Learning force fields from stochastic trajectories

A Frishman, P Ronceray - Physical Review X, 2020 - APS
When monitoring the dynamics of stochastic systems, such as interacting particles agitated
by thermal noise, disentangling deterministic forces from Brownian motion is challenging …

Thermodynamics of active field theories: Energetic cost of coupling to reservoirs

T Markovich, É Fodor, E Tjhung, ME Cates - Physical Review X, 2021 - APS
The hallmark of active matter is the autonomous directed motion of its microscopic
constituents driven by consumption of energy resources. This motion leads to the …

Dissipation and energy propagation across scales in an active cytoskeletal material

PJ Foster, J Bae, B Lemma, J Zheng… - Proceedings of the …, 2023 - National Acad Sciences
Living systems are intrinsically nonequilibrium: They use metabolically derived chemical
energy to power their emergent dynamics and self-organization. A crucial driver of these …

From cytoskeletal assemblies to living materials

PJ Foster, S Fürthauer, MJ Shelley… - Current opinion in cell …, 2019 - Elsevier
Many subcellular structures contain large numbers of cytoskeletal filaments. Such
assemblies underlie much of cell division, motility, signaling, metabolism, and growth. Thus …

Cell-matrix elastocapillary interactions drive pressure-based wetting of cell aggregates

MS Yousafzai, V Yadav, S Amiri, MF Staddon, Y Errami… - Physical Review X, 2022 - APS
The magnitude of mechanical stresses caused by cell surface tension may be comparable to
the bulk elasticity of their matrix on cellular length scales, yet how capillary effects influence …

Estimating time-dependent entropy production from non-equilibrium trajectories

S Otsubo, SK Manikandan, T Sagawa… - Communications …, 2022 - nature.com
The rate of entropy production provides a useful quantitative measure of a non-equilibrium
system and estimating it directly from time-series data from experiments is highly desirable …