Network pharmacology: curing causal mechanisms instead of treating symptoms
For complex diseases, most drugs are highly ineffective, and the success rate of drug
discovery is in constant decline. While low quality, reproducibility issues, and translational …
discovery is in constant decline. While low quality, reproducibility issues, and translational …
[HTML][HTML] Adverse outcomes of polypharmacy in older people: systematic review of reviews
Objective Polypharmacy is widespread among older people, but the adverse outcomes
associated with it are unclear. We aim to synthesize current evidence on the adverse health …
associated with it are unclear. We aim to synthesize current evidence on the adverse health …
[图书][B] The new psychology of health: Unlocking the social cure
British Psychology Society Textbook of the Year 2020 Why do people who are more socially
connected live longer and have better health than those who are socially isolated? Why are …
connected live longer and have better health than those who are socially isolated? Why are …
The epidemiology of polypharmacy in older adults: register-based prospective cohort study
L Morin, K Johnell, ML Laroche, J Fastbom… - Clinical …, 2018 - Taylor & Francis
Objective Polypharmacy is the concomitant use of several drugs by a single person, and it
increases the risk of adverse drug-related events in older adults. Little is known about the …
increases the risk of adverse drug-related events in older adults. Little is known about the …
How does exercise treatment compare with antihypertensive medications? A network meta-analysis of 391 randomised controlled trials assessing exercise and …
Objective To compare the effect of exercise regimens and medications on systolic blood
pressure (SBP). Data sources Medline (via PubMed) and the Cochrane Library. Eligibility …
pressure (SBP). Data sources Medline (via PubMed) and the Cochrane Library. Eligibility …
The health costs of cost-sharing
What happens when patients suddenly stop their medications? We study the health
consequences of drug interruptions caused by large, abrupt, and arbitrary changes in price …
consequences of drug interruptions caused by large, abrupt, and arbitrary changes in price …
Clinical consequences of polypharmacy in elderly
RL Maher, J Hanlon, ER Hajjar - Expert opinion on drug safety, 2014 - Taylor & Francis
Introduction: Polypharmacy, defined as the use of multiple drugs or more than are medically
necessary, is a growing concern for older adults. MEDLINE and EMBASE databases were …
necessary, is a growing concern for older adults. MEDLINE and EMBASE databases were …
Health outcomes associated with polypharmacy in community‐dwelling older adults: a systematic review
TR Fried, J O'Leary, V Towle… - Journal of the …, 2014 - Wiley Online Library
Objectives To summarize evidence regarding the health outcomes associated with
polypharmacy, defined as number of prescribed medications, in older community‐dwelling …
polypharmacy, defined as number of prescribed medications, in older community‐dwelling …
Polypharmacy among adults aged 65 years and older in the United States: 1988–2010
CJ Charlesworth, E Smit, DSH Lee… - … Series A: Biomedical …, 2015 - academic.oup.com
Background. Older adults frequently have several chronic health conditions which require
multiple medications. We illustrated trends in prescription medication use over 20 years in …
multiple medications. We illustrated trends in prescription medication use over 20 years in …
Predicting risk of adverse drug reactions in older adults
AH Lavan, P Gallagher - Therapeutic advances in drug …, 2016 - journals.sagepub.com
Adverse drug reactions (ADRs) are common in older adults, with falls, orthostatic
hypotension, delirium, renal failure, gastrointestinal and intracranial bleeding being amongst …
hypotension, delirium, renal failure, gastrointestinal and intracranial bleeding being amongst …