Targeting signaling pathways in prostate cancer: mechanisms and clinical trials

Y He, W Xu, YT Xiao, H Huang, D Gu… - Signal transduction and …, 2022 - nature.com
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

[HTML][HTML] The role of cholesterol metabolism in cancer

X Ding, W Zhang, S Li, H Yang - American journal of cancer …, 2019 - ncbi.nlm.nih.gov
Cholesterol plays an important role in cancer development. Both clinical and experimental
studies have found that hypercholesterolemia and a high-fat high-cholesterol diet can affect …

[HTML][HTML] Macrophages promote anti-androgen resistance in prostate cancer bone disease

XF Li, C Selli, HL Zhou, J Cao, S Wu, RY Ma… - Journal of Experimental …, 2023 - rupress.org
Metastatic castration-resistant prostate cancer (PC) is the final stage of PC that acquires
resistance to androgen deprivation therapies (ADT). Despite progresses in understanding of …

Non-genomic actions of the androgen receptor in prostate cancer

JK Leung, MD Sadar - Frontiers in endocrinology, 2017 - frontiersin.org
Androgen receptor (AR) is a validated drug target for prostate cancer based on its role in
proliferation, survival, and metastases of prostate cancer cells. Unfortunately, despite recent …

High‐throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

Y Zhu, T Weiss, Q Zhang, R Sun, B Wang… - Molecular …, 2019 - Wiley Online Library
Formalin‐fixed, paraffin‐embedded (FFPE), biobanked tissue samples offer an invaluable
resource for clinical and biomarker research. Here, we developed a pressure cycling …

Unraveling the anticancer effect of curcumin and resveratrol

AR Pavan, GDB Silva, DH Jornada, DE Chiba… - Nutrients, 2016 - mdpi.com
Resveratrol and curcumin are natural products with important therapeutic properties useful
to treat several human diseases, including cancer. In the last years, the number of studies …

Recent advances and future perspectives in the therapeutics of prostate cancer

GL Varaprasad, VK Gupta, K Prasad, E Kim… - … Hematology & Oncology, 2023 - Springer
Prostate cancer (PC) is one of the most common cancers in males and the fifth leading
reason of death. Age, ethnicity, family history, and genetic defects are major factors that …

Mechanistic evaluation of phytochemicals in breast cancer remedy: current understanding and future perspectives

M Younas, C Hano, N Giglioli-Guivarc'h, BH Abbasi - RSC advances, 2018 - pubs.rsc.org
Breast cancer is one of the most commonly diagnosed cancers around the globe and
accounts for a large proportion of fatalities in women. Despite the advancement in …

Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer

Q Tian, P Yuan, C Quan, M Li, J Xiao, L Zhang, H Lu… - Oncogene, 2020 - nature.com
Branched-chain α-keto acid dehydrogenase kinase (BCKDK), the key enzyme of branched-
chain amino acids (BCAAs) metabolism, has been reported to promote colorectal cancer …

Cell plasticity and prostate cancer: The role of epithelial–mesenchymal transition in tumor progression, invasion, metastasis and cancer therapy resistance

S Papanikolaou, A Vourda, S Syggelos, K Gyftopoulos - Cancers, 2021 - mdpi.com
Simple Summary Although epithelial-to-mesenchymal transition (EMT) is a well-known
cellular process involved during normal embryogenesis and wound healing, it also has a …