The Bcl-2 family of proteins controls a critical step in commitment to apoptosis by regulating
permeabilization of the mitochondrial outer membrane (MOM). The family is divided into …

DNA is one of the prime molecules, and its stability is of utmost importance for proper
functioning and existence of all living systems. Genotoxic chemicals and radiations exert …

The maintenance of genome stability depends on the DNA damage response (DDR), which
is a functional network comprising signal transduction, cell cycle regulation and DNA repair …

Bcl-2 family proteins are recognized as major regulators of the mitochondrial pathway of
apoptosis. They control the mitochondrial outer membrane permeabilization (MOMP) by …

The BH3-only proteins of Bcl-2 family are essential initiators of apoptosis that propagate
extrinsic and intrinsic cell death signals. The interaction of BH3-only proteins with other Bcl-2 …

Apoptosis is essential for tissue homeostasis, particularly in the hematopoietic compartment,
where its impairment can elicit neoplastic or autoimmune diseases. Whether stressed cells …

Protein kinases control cellular decision processes by phosphorylating specific substrates.
Thousands of in vivo phosphorylation sites have been identified, mostly by proteome-wide …

Abstract BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis.
They discharge their pro-apoptotic functions through BH1–3 pro-apoptotic proteins such as …

BH3-only members of the Bcl-2 intracellular protein family, which include Bim, Bmf, Bik, Bad,
Bid, Puma, Noxa and Hrk, mediate many developmentally programmed and induced …

Preservation of genome integrity via the DNA-damage response is critical to prevent
disease. ATR (ataxia telangiectasia mutated-and Rad3-related) is essential for life and …