Drug-induced liver injury (DILI) occurs in an incidence of 10 to 15 in 10, 000 to 100,000 in
the United States, 1, 2 yet it has caused remarkable fatalities from acute liver failure yearly …

The liver is the center for drug and xenobiotic metabolism, which is influenced most with
medication/xenobiotic-mediated toxic activity. Drug-induced hepatotoxicity is common and …

Current drug-safety assays for hepatotoxicity rely on biomarkers with low predictive power.
The production of radical species, specifically reactive oxygen species (ROS) and reactive …

Drug-induced liver injury (DILI) is considered a serious problem related to public health, due
to its unpredictability and acute response. The level of peroxynitrite (ONOO–) generated in …

Early diagnosis and detection of drug-induced liver injury (DILI) is great significance for the
effective prevention and treatment of patients with liver injury. Studies indicate that the up …

Background: Drug-induced Liver Injury (DILI) is an important cause of acute liver failure
cases in the United States, and remains a common cause of withdrawal of drugs in both …

Drugs that cause liver injury often 'stress' mitochondria and activate signal transduction
pathways important in determining cell survival or death. In most cases, hepatocytes adapt …

Background The epidemiology of drug-induced liver injury (DILI) in China has rarely been
studied before. The aim of the present study was to determine the etiology of DILI in a …

A novel hepatocyte-targeting near-infrared fluorescent probe named Gal-NIR is developed.
Gal-NIR shows ratiometric response to ONOO− with high sensitivity and selectivity …

Tuberculosis is one of the top causes of death among curable infectious diseases; it is an
airborne infectious disease that killed 1.1 million people worldwide in 2010. Anti …