Hypertension (HTN) is one of the most prevalent diseases worldwide and is among the most
important risk factors for cardiovascular and cerebrovascular complications. It is currently …

Abstract Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by
endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a …

Acute exposure to high-dose gamma radiation due to radiological disasters or cancer
radiotherapy can result in radiation-induced lung injury (RILI), characterized by acute …

NADPH oxidase (Nox) has a dedicated function of generating reactive oxygen species
(ROS). Accumulating evidence suggests that Nox has an important role in signal …

Increased oxidative stress plays an important role in the pathophysiology of cardiovascular
diseases such as hypertension, atherosclerosis, diabetes, cardiac hypertrophy, heart failure …

Oxidative stress has been established as a well-known pathological condition in several
neurovascular diseases. It starts with increased production of highly oxidizing free-radicals …

Nitric oxide (NO) and endothelin-1 (ET-1) are natural counterparts in vascular function, and it
is becoming increasingly clear that an imbalance between these two mediators is a …

Glomerular endothelial cell (GEnC) dysfunction is important in the pathogenesis of
glomerular sclerotic diseases, including Focal Segmental Glomerulosclerosis (FSGS) and …

Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-
1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a …

Atherosclerotic peripheral artery disease primarily manifests in the medium-to large-sized
conduit arteries of the lower extremities. However, the factors underlying this increased …