Diffusion MRI (dMRI) has proven to be a useful imaging approach for both clinical diagnosis
and research investigating the microstructures of nervous tissues, and it has helped us to …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …

Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …

Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …

There has been an increasing prevalence of neurodegenerative diseases with the rapid
increase in aging societies worldwide. Biomarkers that can be used to detect pathological …

Objectives Agitation and aggression are common in dementia and pre‐dementia. The
dementia risk syndrome mild behavioral impairment (MBI) includes these symptoms in the …

Background Mild behavioral impairment (MBI) is a syndrome that uses later‐life emergent
and persistent neuropsychiatric symptoms (NPS) to identify a group at high risk for incident …

Beta-amyloid (Aβ) and tau proteins, the pathological hallmarks of Alzheimer's disease (AD),
are believed to spread through connected regions of the brain. Combining diffusion imaging …

White matter microstructure undergoes progressive changes during the lifespan, but the
neurobiological underpinnings related to ageing and disease remains unclear. We used an …