Doxorubicin (Dox) is a secondary metabolite of the mutated strain of Streptomyces peucetius
var. Caesius and belongs to the anthracyclines family. The anti-cancer activity of Dox is …

The utility of anthracycline antineoplastic agents in the clinic is compromised by the risk of
cardiotoxicity. It has been calculated that approximately 10% of patients treated with …

The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1
and-2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas …

Hypertension (HTN) is one of the most prevalent diseases worldwide and is among the most
important risk factors for cardiovascular and cerebrovascular complications. It is currently …

The onset of cardiomyopathy is a common feature in sepsis, with relevant effects on its
pathophysiology and clinical care. Septic cardiomyopathy is characterized by reduced left …

Sepsis is generally viewed as a disease aggravated by an inappropriate immune response
encountered in the afflicted individual. As an important organ system frequently …

Abstract Endothelin (ET)-1 is a potent vasoconstrictor peptide originally isolated from
endothelial cells. Its production is stimulated in a variety of different cell types under the …

Adrenergic receptors (AR) are G-protein-coupled receptors (GPCRs) that have a crucial role
in cardiac physiology in health and disease. Alpha1-ARs signal through G α q, and signaling …

Increasing evidence points to insulin resistance as a primary etiologic factor in the
development of nonischemic heart failure (HF). The myocardium normally responds to injury …

Macitentan, also called Actelion-1 or ACT-064992 [N-[5-(4-bromophenyl)-6-(2-(5-
bromopyrimidin-2-yloxy) ethoxy)-pyrimidin-4-yl]-N′-propylaminosulfonamide], is a new …