Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

The fungal cell wall is located outside the plasma membrane and is the cell compartment
that mediates all the relationships of the cell with the environment. It protects the contents of …

Vast efforts have been devoted to the development of antifungal drugs targeting the cell wall,
but the supramolecular architecture of this carbohydrate-rich composite remains …

Inflammasomes are important sentinels of innate immune defence that are activated in
response to diverse stimuli, including pathogen-associated molecular patterns (PAMPs) …

Chitin is a major carbohydrate component of the fungal cell wall and a promising target for
novel antifungal agents. However, it is technically challenging to characterize the structure of …

More than 90% of the cell wall of the filamentous fungus Aspergillus fumigatus comprises
polysaccharides. Biosynthesis of the cell wall polysaccharides is under the control of three …

Fungal cell walls play dynamic functions in interaction of fungi with their surroundings. In
pathogenic fungi, the cell wall is the first structure to make physical contact with host cells …

Aspergillus fumigatus is the most important airborne fungal pathogen, causing severe
infections with invasive growth in immunocompromised patients. The fungal cell wall (CW) …

Antifungal echinocandins inhibit the biosynthesis of β− 1, 3-glucan, a major and essential
polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins …

Hyphae represent a hallmark structure of multicellular fungi. The evolutionary origins of
hyphae and of the underlying genes are, however, hardly known. By systematically …