Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition

CE Finch - Proceedings of the National Academy of …, 2010 - National Acad Sciences
Humans have evolved much longer lifespans than the great apes, which rarely exceed 50
years. Since 1800, lifespans have doubled again, largely due to improvements in …

APOE Alleles and Diet in Brain Aging and Alzheimer's Disease

HN Yassine, CE Finch - Frontiers in aging neuroscience, 2020 - frontiersin.org
The APOE gene alleles modify human aging and the response to the diet at many levels
with diverse pleotropic effects from gut to brain. To understand the interactions of APOE …

[HTML][HTML] Beyond the CNS: the many peripheral roles of APOE

AB Martínez-Martínez, E Torres-Perez… - Neurobiology of …, 2020 - Elsevier
Apolipoprotein E (APOE) is a multifunctional protein synthesized and secreted by multiple
mammalian tissues. Although hepatocytes contribute about 75% of the peripheral pool …

The development and endocrine functions of adipose tissue

SP Poulos, DB Hausman, GJ Hausman - Molecular and cellular …, 2010 - Elsevier
White adipose tissue is a mesenchymal tissue that begins developing in the fetus.
Classically known for storing the body's fuel reserves, adipose tissue is now recognized as …

APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

BC Farmer, HC Williams, NA Devanney… - Molecular …, 2021 - Springer
Background Cerebral glucose hypometabolism is consistently observed in individuals with
Alzheimer's disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of …

Apolipoprotein E in cardiometabolic and neurological health and diseases

J Alagarsamy, A Jaeschke, DY Hui - International Journal of Molecular …, 2022 - mdpi.com
A preponderance of evidence obtained from genetically modified mice and human
population studies reveals the association of apolipoprotein E (apoE) deficiency and …

Cell-specific production, secretion, and function of apolipoprotein E

M Kockx, M Traini, L Kritharides - Journal of molecular medicine, 2018 - Springer
Apolipoprotein E (apoE) is a 34-kDa glycoprotein that is secreted from many cells
throughout the body. ApoE is best known for its role in lipoprotein metabolism. Recent …

Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond

AA Pendse, JM Arbones-Mainar, LA Johnson… - Journal of lipid …, 2009 - ASBMB
Given the multiple differences between mice and men, it was once thought that mice could
not be used to model atherosclerosis, principally a human disease. Apolipoprotein E …

[HTML][HTML] Alzheimer's disease pathology in APOE transgenic mouse models: the who, what, when, where, why, and how

CT Lewandowski, JM Weng, MJ LaDu - Neurobiology of disease, 2020 - Elsevier
The focus on amyloid plaques and neurofibrillary tangles has yielded no Alzheimer's
disease (AD) modifying treatments in the past several decades, despite successful studies in …

Sex differences in cognition across aging

BH Lee, JE Richard, RG de Leon, S Yagi… - Sex differences in brain …, 2022 - Springer
Sex and gender differences are seen in cognitive disturbances in a variety of neurological
and psychiatry diseases. Men are more likely to have cognitive symptoms in schizophrenia …