Abstract Streptococcus pyogenes (Group A Streptococcus; GAS) is exquisitely adapted to
the human host, resulting in asymptomatic infection, pharyngitis, pyoderma, scarlet fever or …

The cellular degradative pathway of autophagy has a fundamental role in immunity. Here,
we review the function of autophagy and autophagy proteins in inflammation. We discuss …

Gasdermins, a family of five pore-forming proteins (GSDMA–GSDME) in humans expressed
predominantly in the skin, mucosa and immune sentinel cells, are key executioners of …

Gasdermins (GSDMs) are a family of pore-forming effectors that permeabilize the cell
membrane during the cell death program pyroptosis. GSDMs are activated by proteolytic …

Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy, a cellular homeostatic process, which ensures cellular survival under various
stress conditions, has catapulted to the forefront of innate defense mechanisms during …

Intracellular pathogens have evolved various efficient molecular armaments to subvert
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …

Group A Streptococcus (GAS; Streptococcus pyogenes) is a nearly ubiquitous human
pathogen responsible for a significant global disease burden. No vaccine exists, so …

Research in recent years has focused significantly on the role of selective macroautophagy
in targeting intracellular pathogens for lysosomal degradation, a process termed xenophagy …