Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we
will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

This review focuses on the systemic complications of acromegaly. Mortality in this disease is
increased mostly because of cardiovascular and respiratory diseases, although currently …

INSULIN-LIKE growth factor-I (IGF-I) and IGF-II growth factors that are structurally related to
insulin (Table 1). The human IGFs (refered to generically as somatomedins) are single chain …

Since the original somatomedin hypothesis was conceived, a number of important
discoveries have allowed investigators to modify the concept. Originally somatic growth was …

Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in
response to the endocrine GH stimulus, but it is also secreted by multiple tissues for …

▪ Abstract The traditionally accepted theory has been that most of the biological effects of
growth hormone (GH) are mediated by circulating (endocrine) insulin-like growth factor-I …

Insulin-like growth factors I and II (IGF-I and-II) and their regulatory proteins are secreted by
cells of the cardiovascular system. They are growth promoters for arterial cells and …

Abstract" The insulin-like growth factors (IGF-I and IGF-II) are small polypeptides (Mr-7500)
that control growth of multiple cell types. Cells derived from all three embryonic lineages …

A complex network of mediator molecules constitutes a communication system coordinating
different cells and tissues within the body, thus maintaining or restoring physiological …