Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions
Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, developing drugs for central nervous system (CNS) disorders remains the most …
However, developing drugs for central nervous system (CNS) disorders remains the most …
Metformin and the gastrointestinal tract
LJ McCreight, CJ Bailey, ER Pearson - Diabetologia, 2016 - Springer
Metformin is an effective agent with a good safety profile that is widely used as a first-line
treatment for type 2 diabetes, yet its mechanisms of action and variability in terms of efficacy …
treatment for type 2 diabetes, yet its mechanisms of action and variability in terms of efficacy …
Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study
Aims/hypothesis Individuals with type 2 diabetes have an altered bacterial composition of
their gut microbiota compared with non-diabetic individuals. However, these alterations may …
their gut microbiota compared with non-diabetic individuals. However, these alterations may …
A simple representation of three-dimensional molecular structure
Statistical and machine learning approaches predict drug-to-target relationships from 2D
small-molecule topology patterns. One might expect 3D information to improve these …
small-molecule topology patterns. One might expect 3D information to improve these …
Alterations of the predominant fecal microbiota and disruption of the gut mucosal barrier in patients with early‐stage colorectal cancer
X Liu, Y Cheng, L Shao, Z Ling - BioMed research international, 2020 - Wiley Online Library
Growing evidence indicated that the gut microbiota was the intrinsic and essential
component of the cancer microenvironment, which played vital roles in the development and …
component of the cancer microenvironment, which played vital roles in the development and …
Effects of medications on heat loss capacity in chronic disease patients: health implications amidst global warming
Pharmacological agents used to treat or manage diseases can modify the level of heat strain
experienced by chronically ill and elderly patients via different mechanistic pathways …
experienced by chronically ill and elderly patients via different mechanistic pathways …
Validation strategies for target prediction methods
Computational methods for target prediction, based on molecular similarity and network-
based approaches, machine learning, docking and others, have evolved as valuable and …
based approaches, machine learning, docking and others, have evolved as valuable and …
Organic cation transporters in the lung—current and emerging (patho) physiological and pharmacological concepts
Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1
and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of …
and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of …
[HTML][HTML] Metformin-induced anticancer activities: recent insights
Metformin is a widely used antidiabetic drug, and there is evidence among diabetic patients
that metformin is a chemopreventive agent against multiple cancers. There is also evidence …
that metformin is a chemopreventive agent against multiple cancers. There is also evidence …
Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of …
K Nabrdalik, K Skonieczna-Żydecka, K Irlik… - Frontiers in …, 2022 - frontiersin.org
Introduction Metformin is the first choice drug in the treatment of type 2 diabetes mellitus but
its administration may be linked to gastrointestinal adverse events limiting its use. Objectives …
its administration may be linked to gastrointestinal adverse events limiting its use. Objectives …