The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …
tuberculosis remains out of control in several parts of the world including Africa and Asia …
Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment
A Allué-Guardia, JI García, JB Torrelles - Frontiers in Microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …
Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …
Fast and flexible bacterial genomic epidemiology with PopPUNK
The routine use of genomics for disease surveillance provides the opportunity for high-
resolution bacterial epidemiology. Current whole-genome clustering and multilocus typing …
resolution bacterial epidemiology. Current whole-genome clustering and multilocus typing …
Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care
N Dookie, S Rambaran, N Padayatchi… - Journal of …, 2018 - academic.oup.com
Abstract Drug-resistant TB (DR-TB) remains a significant challenge in TB treatment and
control programmes worldwide. Advances in sequencing technology have significantly …
control programmes worldwide. Advances in sequencing technology have significantly …
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
To characterize the genetic determinants of resistance to antituberculosis drugs, we
performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis …
performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis …
Same-day diagnostic and surveillance data for tuberculosis via whole-genome sequencing of direct respiratory samples
AA Votintseva, P Bradley, L Pankhurst… - Journal of clinical …, 2017 - Am Soc Microbiol
Routine full characterization of Mycobacterium tuberculosis is culture based, taking many
weeks. Whole-genome sequencing (WGS) can generate antibiotic susceptibility profiles to …
weeks. Whole-genome sequencing (WGS) can generate antibiotic susceptibility profiles to …
Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance
Multidrug-resistant tuberculosis (MDR-TB), caused by drug-resistant strains of
Mycobacterium tuberculosis, is an increasingly serious problem worldwide. Here we …
Mycobacterium tuberculosis, is an increasingly serious problem worldwide. Here we …
Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs
Background Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major
threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction …
threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction …
Transmission of multidrug-resistant Mycobacterium tuberculosis in Shanghai, China: a retrospective observational study using whole-genome sequencing and …
Background Multidrug-resistance is a substantial threat to global elimination of tuberculosis.
Understanding transmission patterns is crucial for control of the disease. We used a …
Understanding transmission patterns is crucial for control of the disease. We used a …