The good, the bad and the unknown aspects of ghrelin in stress coping and stress-related psychiatric disorders

EM Fritz, N Singewald, D De Bundel - Frontiers in synaptic …, 2020 - frontiersin.org
Ghrelin is a peptide hormone released by specialized X/A cells in the stomach and activated
by acylation. Following its secretion, it binds to ghrelin receptors in the periphery to regulate …

The ghrelin axis—does it have an appetite for cancer progression?

LK Chopin, I Seim, CM Walpole… - Endocrine …, 2012 - academic.oup.com
Ghrelin, the endogenous ligand for the GH secretagogue receptor (GHSR), is a peptide
hormone with diverse physiological roles. Ghrelin regulates GH release, appetite and …

Ghrelin indirectly activates hypophysiotropic CRF neurons in rodents

A Cabral, O Suescun, JM Zigman, M Perello - PloS one, 2012 - journals.plos.org
Ghrelin is a stomach-derived hormone that regulates food intake and neuroendocrine
function by acting on its receptor, GHSR (G rowth H ormone S ecretagogue R eceptor) …

Altered metabolic and neurochemical responses to chronic unpredictable stressors in ghrelin receptor‐deficient mice

ZR Patterson, R Ducharme, H Anisman… - European Journal of …, 2010 - Wiley Online Library
Ghrelin, a hormone produced by the stomach, is generally associated with feeding
responses and the regulation of food intake. Recent evidence, however, suggests that …

Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence

C Hansson, D Haage, M Taube, E Egecioglu… - Neuroscience, 2011 - Elsevier
The orexigenic and pro-obesity hormone ghrelin targets key hypothalamic and mesolimbic
circuits involved in energy balance, appetite and reward. Given that such circuits are closely …

Neuroendocrine and neuroimmune mechanisms underlying comorbidity of pain and obesity

DH Zhang, YH Fan, YQ Zhang, H Cao - Life Sciences, 2023 - Elsevier
Pain and obesity, as well as their associated impairments, are major health concerns.
Understanding the relationship between the two is the focus of a growing body of research …

Ghrelin stimulation by hypothalamic–pituitary–adrenal axis activation depends on increasing cortisol levels

I Azzam, S Gilad, R Limor, N Stern… - Endocrine …, 2017 - ec.bioscientifica.com
Ghrelin plasma concentration increases in parallel to cortisol after a standardized
psychological stress in humans, but the physiological basis of this interaction is unknown …

Lifestyle factors and ghrelin: critical review and implications for weight loss maintenance

CE Adams, FL Greenway, PJ Brantley - Obesity Reviews, 2011 - Wiley Online Library
Ghrelin, the only known appetite‐stimulating hormone in humans, may be one factor
involved in increased appetite, cravings and food intake following weight loss. Innovative …

What is the general action of ghrelin for vertebrates?–Comparisons of ghrelin's effects across vertebrates

H Kaiya, K Kangawa, M Miyazato - General and Comparative …, 2013 - Elsevier
Ten years and more passed since ghrelin was discovered. Various physiological actions of
ghrelin have been documented in both mammalian and nonmammalian vertebrates. Do …

Mice with hyperghrelinemia are hyperphagic and glucose intolerant and have reduced leptin sensitivity

GA Bewick, A Kent, D Campbell, M Patterson… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Ghrelin is the only known peripheral hormone to increase ingestive behavior.
However, its role in the physiological regulation of energy homeostasis is unclear because …