Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …

Emerging evidence shows a broad spectrum of biological functions of tissue factor (TF). TF
classical role in initiating the extrinsic blood coagulation and its direct thrombotic action in …

Venous thromboembolism (VTE) which includes deep vein thrombosis (DVT) and
pulmonary thromboembolism (PTE) is a moderately common disease especially in elderly …

Platelet α-granules constitute the major rapidly releasable reservoir of thrombospondin-1 in
higher animals. Although some fragments and peptides derived from thrombospondin-1 …

Nitric oxide (NO) is a powerful biological mediator provided with a number of activities of
relevance for the prevention of thrombosis, like vasodilation, inhibition of platelet adhesion …

Extracorporeal shock wave therapy (ESWT) can improve flap survival, but its mechanism
remains unclear. In this study, we aim to investigate whether ESWT can improve blood flow …

Thrombospondin-1 is a secreted protein that modulates vascular cell behavior via several
cell surface receptors. In vitro, nanomolar concentrations of thrombospondin-1 are required …

Nonalcoholic steatohepatitis (NASH) is associated with an increased risk of developing
cardiovascular complications and mortality, suggesting that treatment of NASH might benefit …

Abacavir (ABC) has been associated with ischaemic cardiovascular events in HIV-infected
patients, but the pathogenic mechanisms are unknown. Aim of our study was to assess …

This review describes the laboratory evidence and microvascular mechanisms responsible
for the beneficial effects of statins in sepsis. During sepsis, changes occur within the …