As an emerging sequencing technology, single-cell RNA sequencing (scRNA-Seq) has
become a powerful tool for describing cell subpopulation classification and cell …

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …

During embryogenesis, waves of hematopoietic progenitors develop from hemogenic
endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs) …

T cells show tremendous efficacy as cellular therapeutics. However, obtaining primary T
cells from human donors is expensive and variable. Pluripotent stem cells (PSCs) have the …

It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells
(HSCs) in the bone marrow and that HSC-independent hematopoiesis is limited only to …

Skull base chordoma (SBC) is a bone cancer with a high recurrence rate, high
radioresistance rate, and poorly understood mechanism. Here, we profiled the …

Developmental hematopoiesis consists of multiple, partially overlapping hematopoietic
waves that generate the differentiated blood cells required for embryonic development while …

Regenerative medicine harnesses the body's innate capacity for self-repair to restore
malfunctioning tissues and organs. Stem cell therapies represent a key regenerative …

It has been over three decades since Drs. Herzenberg and Herzenberg proposed the
layered immune system hypothesis, suggesting that different types of stem cells with distinct …

The journey of a hematopoietic stem cell (HSC) involves the passage through successive
anatomical sites where HSCs are in direct contact with their surrounding microenvironment …