In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …

Immune checkpoint blockade (ICB) has revolutionized modern cancer therapy, arousing
great interest in the neuro-oncology community. While several reports show that subsets of …

Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma
cells forms a functional and therapy-resistant tumor cell network interconnected by tumor …

The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify
treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …

Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …

Single-cell RNA sequencing has revealed extensive transcriptional cell state diversity in
cancer, often observed independently of genetic heterogeneity, raising the central question …

Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …

Glioblastoma (GBM) is an aggressive brain cancer with an immunosuppressive tumor
microenvironment. Here, a copper-based nanoplatform BSO-CAT@ MOF-199@ DDM …

Glioblastoma (GBM) is an intractable malignancy with high recurrence and mortality.
Combinatorial therapy based on temozolomide (TMZ) and cisplatin (CDDP) shows …

Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …