Biomaterials to mimic and heal connective tissues

BR Freedman, DJ Mooney - Advanced Materials, 2019 - Wiley Online Library
Connective tissue is one of the four major types of animal tissue and plays essential roles
throughout the human body. Genetic factors, aging, and trauma all contribute to connective …

Fatigue-free artificial ionic skin toughened by self-healable elastic nanomesh

J Wang, B Wu, P Wei, S Sun, P Wu - Nature Communications, 2022 - nature.com
Robust ionic sensing materials that are both fatigue-resistant and self-healable like human
skin are essential for soft electronics and robotics with extended service life. However, most …

Exploring the role of intratendinous pressure in the pathogenesis of tendon pathology: a narrative review and conceptual framework

L Pringels, JL Cook, E Witvrouw, A Burssens… - British journal of sports …, 2023 - bjsm.bmj.com
Despite the high prevalence of tendon pathology in athletes, the underlying pathogenesis is
still poorly understood. Various aetiological theories have been presented and rejected in …

Visco‐poroelastic electrochemiluminescence skin with piezo‐ionic effect

JI Lee, H Choi, SH Kong, S Park, D Park… - Advanced …, 2021 - Wiley Online Library
Following early research efforts devoted to achieving excellent sensitivity of electronic skins,
recent design schemes for these devices have focused on strategies for transduction of …

Strong triaxial coupling and anomalous Poisson effect in collagen networks

E Ban, H Wang, JM Franklin… - Proceedings of the …, 2019 - National Acad Sciences
While cells within tissues generate and sense 3D states of strain, the current understanding
of the mechanics of fibrous extracellular matrices (ECMs) stems mainly from uniaxial, biaxial …

Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: Application to tendon and skin biophysics

R Oftadeh, BK Connizzo, HT Nia, C Ortiz… - Acta biomaterialia, 2018 - Elsevier
In this study, a poroviscoelastic finite element model (FEM) was developed and used in
conjunction with an AFM-based wide-bandwidth nanorheology system to predict the …

Compressibility and anisotropy of the ventricular myocardium: experimental analysis and microstructural modeling

E McEvoy, GA Holzapfel… - Journal of …, 2018 - asmedigitalcollection.asme.org
While the anisotropic behavior of the complex composite myocardial tissue has been well
characterized in recent years, the compressibility of the tissue has not been rigorously …

Tendon exhibits complex poroelastic behavior at the nanoscale as revealed by high-frequency AFM-based rheology

BK Connizzo, AJ Grodzinsky - Journal of biomechanics, 2017 - Elsevier
Tendons transmit load from muscle to bone by utilizing their unique static and viscoelastic
tensile properties. These properties are highly dependent on the composition and structure …

Evidence that interfibrillar load transfer in tendon is supported by small diameter fibrils and not extrafibrillar tissue components

SE Szczesny, KL Fetchko, GR Dodge… - Journal of Orthopaedic …, 2017 - Wiley Online Library
Collagen fibrils in tendon are believed to be discontinuous and transfer tensile loads
through shear forces generated during interfibrillar sliding. However, the structures that …

Digital image correlation-aided mechanical characterization of the anteromedial and posterolateral bundles of the anterior cruciate ligament

KF Mallett, EM Arruda - Acta biomaterialia, 2017 - Elsevier
The anterior cruciate ligament (ACL) is one of the most commonly injured soft tissue
structures in the articular knee joint, often requiring invasive surgery for patients to restore …