Bone is an extremely dynamic tissue, undergoing continuous remodeling for its whole
lifetime, but its regeneration or augmentation due to bone loss or defects are not always …

Biomineralization can be considered as nature's strategy to produce and sustain
biominerals, primarily via creation of hard tissues for protection and support. This review …

Tremendous advances in tissue engineering and regenerative medicine have revealed the
potential of fabricating biomaterials to solve the dilemma of bone and articular defects by …

Bone remodelling is a dynamic process required for the maintenance of bone architecture in
response to the changing mechanical needs. It is also a vital process during the repair of …

Bone is a highly vascularized tissue, in which vascularization and mineralization are
concurrent processes during skeletal development. Indeed, both components should be …

Heterogeneity describes the differences among cancer cells within and between tumors. It
refers to cancer cells describing variations in morphology, transcriptional profiles …

The repair of bone defects caused by trauma, infection or tumor resection is a major clinical
orthopedic challenge. The application of bone grafts in orthopedic procedures is associated …

3-dimensional (3D) in vitro models were developed in order to mimic the complexity of real
organ/tissue in a dish. They offer new possibilities to model biological processes in more …

Silicon and glass were the main fabrication materials of microfluidic devices, however,
plastics are on the rise in the past few years. Thermoplastic materials have recently been …

The superiority of in vitro 3D cultures over conventional 2D cell cultures is well recognized
by the scientific community for its relevance in mimicking the native tissue architecture and …