Prerequisite to any biological laboratory assay employing living animals is consideration
about its necessity, feasibility, ethics and the potential harm caused during an experiment …

The molecular mechanism essential for the formation of heart valves involves complex
interactions of signaling molecules and transcription factors. The Mediator Complex (MC) …

In the zebrafish embryo, the onset of blood flow generates fluid shear stress on endocardial
cells, which are specialized endothelial cells that line the interior of the heart. High levels of …

Neural crest cells migrate to the embryonic heart and transform into a small number of
cardiomyocytes, but their functions in the developing and adult heart are unknown. Here, we …

Cerebral cavernous malformations (CCMs) are anomalies of the cerebral vasculature. Loss
of the CCM proteins CCM1/KRIT1, CCM2, or CCM3/PDCD10 trigger a MAPK-Krüppel-like …

Genetic testing for inherited arrhythmias and discriminating pathogenic or benign variants
from variants of unknown significance (VUS) is essential for gene-based medicine. KCNQ1 …

The atrioventricular canal (AVC) is the site where key structures responsible for functional
division between heart regions are established, most importantly, the atrioventricular (AV) …

Contrary to adult mammals, zebrafish are able to regenerate their heart after cardiac injury.
This regenerative response relies, in part, on the endogenous ability of cardiomyocytes …

Congenital heart disease (CHD) is the most common birth defect worldwide and a main
cause of perinatal and infant mortality. Our previous genome-wide association study …

The formation of cardiac valves depends on mechanical forces exerted by blood flow.
Endocardial cells lining the interior of the heart are sensitive to these stimuli and respond by …