Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

Life-history traits or “fitness components”—such as age and size at maturity, fecundity and
fertility, age-specific rates of survival, and life span—are the major phenotypic determinants …

Nutrition has long been considered more the domain of medicine and agriculture than of the
biological sciences, yet it touches and shapes all aspects of the natural world. The need for …

Most research on nutritional effects on aging has focussed on the impact of manipulating
single dietary factors such as total calorie intake or each of the macronutrients individually …

Modest dietary restriction extends lifespan (LS) in a diverse range of taxa and typically has a
larger effect in females than males. Traditionally, this has been attributed to a stronger trade …

The gastrointestinal tract is emerging as a key regulator of appetite and metabolism, but
daunting neuroanatomical complexity has hampered identification of the relevant signals …

The main objective of this review is to provide an appraisal of the current status of the
relationship between energy intake and the life span of animals. The concept that a …

High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases
including type 2 diabetes and shortened lifespan. However, the impact of obesity and water …

Almost exactly 100 years ago Osborne and colleagues demonstrated that restricting the food
intake of a small number of female rats extended their lifespan. In the 1930s experiments on …

Food intake is a fundamental parameter in animal studies. Despite the prevalent use of
Drosophila in laboratory research, precise measurements of food intake remain challenging …