Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

Resistin, originally described as an adipocyte‐specific hormone, has been suggested to be
an important link between obesity, insulin resistance and diabetes. Although its expression …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

Background Retinopathy commonly occurs in people with type 1 diabetes. Strict glycaemic
control can decrease development and progression of retinopathy only partially. Blood …

The amino-terminal amino acid sequence and several internal peptide sequences of
angiotensin I-converting enzyme (ACE; peptidyl-dipeptidase A, kininase II; EC 3.4. 15.1) …

Angiotensin-converting enzyme (ACE) is a zinc-dependent peptidase responsible for
converting angiotensin I into the vasoconstrictor angiotensin II. However, ACE is a relatively …

Plasminogen activator-inhibitor C-1 (PAI-1) plays a critical role in the regulation of
fibrinolysis, serving as the primary inhibitor of tissue-type plasminogen activator. Elevated …

Recent findings have shed new light on the role of peripheral nerves in the skin and
established a modern concept of cutaneous neurobiology. Closely related monodirectional …

The expression of angiotensin-I converting enzyme (ACE; EC 3.4. 15.1) in human circulating
mononuclear cells was studied. T-lymphocytes contained the highest level of enzyme …

The interaction between components of the nervous system and multiple target cells in the
cutaneous immune system has been receiving increasing attention. It has been observed …