Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Over the last two decades, N-acylhydrazone (NAH) has been proven to be a very versatile
and promising motif in drug design and medicinal chemistry. Herein, we discuss the current …

Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

Adipocytes play important roles in regulating cardiovascular health and disease. However,
the molecular mechanism underlying the endocrine role of brown adipose tissue (BAT) in …

The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …

Increasing evidence demonstrated the relevance of adenosine system in the onset and
development of cardiovascular diseases, such as hypertension, myocardial infarct …

Nine novel hydrazone derivatives (4a–i) incorporating pyridine and isatin moieties were
synthesized through one‐pot, four‐component heterocyclic condensation reactions. The …

Myocardial infarction (MI) is a dramatic event often caused by atherosclerotic plaque erosion
or rupture and subsequent thrombotic occlusion of a coronary vessel. The low supply of …

The N‐acylhydrazone motif has been shown to be particularly adaptable and promising in
the area of medicinal chemistry and drug development, due to its significant biological and …