Antisense technology: an overview and prospectus

ST Crooke, BF Baker, RM Crooke… - Nature reviews Drug …, 2021 - nature.com
Antisense technology is now beginning to deliver on its promise to treat diseases by
targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs representing …

RNAi-based therapeutics and novel RNA bioengineering technologies

GM Traber, AM Yu - Journal of Pharmacology and Experimental …, 2023 - ASPET
RNA interference (RNAi) provides researchers with a versatile means to modulate target
gene expression. The major forms of RNAi molecules, genome-derived microRNAs …

[HTML][HTML] Therapeutic advances of miRNAs: A preclinical and clinical update

C Chakraborty, AR Sharma, G Sharma… - Journal of advanced …, 2021 - Elsevier
Background miRNAs, a class of small endogenous RNAs, are one of the essential
biopharmaceuticals which are in commercial spans as next-generation medicine in recent …

MicroRNAs as therapeutic targets in cardiovascular disease

B Laggerbauer, S Engelhardt - The Journal of clinical …, 2022 - Am Soc Clin Investig
The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …

Therapeutic strategies for enhancing angiogenesis in wound healing

AP Veith, K Henderson, A Spencer, AD Sligar… - Advanced drug delivery …, 2019 - Elsevier
The enhancement of wound healing has been a goal of medical practitioners for thousands
of years. The development of chronic, non-healing wounds is a persistent medical problem …

Paving the road for RNA therapeutics

N Dammes, D Peer - Trends in pharmacological sciences, 2020 - cell.com
Therapeutic RNA molecules possess high potential for treating medical conditions if they
can successfully reach the target cell upon administration. However, unmodified RNA …

Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches

J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

Therapeutic miRNA and siRNA: moving from bench to clinic as next generation medicine

C Chakraborty, AR Sharma, G Sharma… - … Therapy-Nucleic Acids, 2017 - cell.com
In the past few years, therapeutic microRNA (miRNA) and small interfering RNA (siRNA) are
some of the most important biopharmaceuticals that are in commercial space as future …

A comprehensive review of cancer MicroRNA therapeutic delivery strategies

A Forterre, H Komuro, S Aminova, M Harada - Cancers, 2020 - mdpi.com
In the field of molecular oncology, microRNAs (miRNAs) and their role in regulating
physiological processes and cancer pathogenesis have been a revolutionary discovery over …

Clinical delivery of circular RNA: lessons learned from RNA drug development

TL Young, KC Wang, AJ Varley, B Li - Advanced drug delivery reviews, 2023 - Elsevier
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …