How much is too much? Interleukin-6 and its signalling in atherosclerosis

H Schuett, M Luchtefeld, C Grothusen… - Thrombosis and …, 2009 - thieme-connect.com
The importance of inflammation as a driver of pathology is no longer confined to
autoimmune and infectious diseases. In line with convincing experimental data as well as …

NF‐κB as the mediator of metformin's effect on ageing and ageing‐related diseases

G Kanigur Sultuybek, T Soydas… - Clinical and …, 2019 - Wiley Online Library
Ageing can be defined as the progressive failure of repair and maintenance systems with a
consequent accumulation of cellular damage in nucleic acids, proteins, and lipids. These …

Pathophysiology of chronic nonhealing wounds

A Medina, PG Scott, A Ghahary… - Journal of Burn Care & …, 2005 - academic.oup.com
Wound healing is a sum of interrelated events whose common aim is the restoration of
injured tissue. This dynamic system includes a number of components, such as epidermal …

Predictive value of IL-8 for sepsis and severe infections after burn injury: a clinical study

R Kraft, DN Herndon, CC Finnerty, RA Cox, J Song… - Shock, 2015 - journals.lww.com
The inflammatory response induced by burn injury contributes to increased incidence of
infections, sepsis, organ failure, and mortality. Thus, monitoring postburn inflammation is of …

Activity of two hyaluronan preparations on primary human oral fibroblasts

MB Asparuhova, D Kiryak, M Eliezer… - Journal of …, 2019 - Wiley Online Library
Background and Objective The potential benefit of using hyaluronan (HA) in reconstructive
periodontal surgery is still a matter of debate. The aim of the present study was to evaluate …

Selective endothelial hyperactivation of oncogenic KRAS induces brain arteriovenous malformations in mice

ES Park, S Kim, S Huang, JY Yoo, J Körbelin… - Annals of …, 2021 - Wiley Online Library
Objective Brain arteriovenous malformations (bAVMs) are a leading cause of hemorrhagic
stroke and neurological deficits in children and young adults, however, no pharmacological …

Inhibitory effect of quercetin on propionibacterium acnes-induced skin inflammation

HJ Lim, SH Kang, YJ Song, YD Jeon, JS Jin - International …, 2021 - Elsevier
Quercetin is a well-known antioxidant and a plant polyphenolic of flavonoid group found in
many fruits, leaves, and vegetables. Propionibacterium acnes is a key skin pathogen …

[HTML][HTML] Functional implications of the IL-6 signaling pathway in keloid pathogenesis

M Ghazizadeh, M Tosa, H Shimizu… - Journal of investigative …, 2007 - Elsevier
The molecular mechanism (s) behind keloid pathogenesis remains unclear. Previously by
global gene expression analysis of keloid fibroblasts (KFs), we implicated the IL-6 signaling …

Regulatory mechanisms of the Wnt/β-catenin pathway in diabetic cutaneous ulcers

H Zhang, X Nie, X Shi, J Zhao, Y Chen, Q Yao… - Frontiers in …, 2018 - frontiersin.org
Skin ulcers are a serious complication of diabetes. Diabetic patients suffer from vascular
lesions and complications such as peripheral neuritis, peripheral vascular lesions, and …

Evidence of inflammatory cell involvement in brain arteriovenous malformations

Y Chen, W Zhu, AW Bollen, MT Lawton… - …, 2008 - journals.lww.com
OBJECTIVE: Brain arteriovenous malformations (AVM) have high matrix metalloproteinase-
9, interleukin-6, and myeloperoxidase (MPO) expression, and polymorphic variations in …