Micronuclei (MN) are extra-nuclear bodies that contain damaged chromosome fragments
and/or whole chromosomes that were not incorporated into the nucleus after cell division …

Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of
silencing gene expression in a range of organisms. The silencing of a gene is a …

The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and
the subsequent recruitment of chromodomain proteins such as heterochromatin protein …

The specialized ribonuclease Dicer initiates RNA interference by cleaving double-stranded
RNA (dsRNA) substrates into small fragments about 25 nucleotides in length. In the crystal …

Eukaryotic DNA is organized into structurally distinct domains that regulate gene expression
and chromosome behavior. Epigenetically heritable domains of heterochromatin control the …

Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate
sequence-specific regulation of diverse biological processes. Here, we combine deep …

Do non-coding RNAs that are derived from the introns and exons of protein-coding and non-
protein-coding genes represent a fundamental advance in the genetic operating system of …

Increasing evidence indicates that chromatin modifications are important regulators of
mammalian telomeres. Telomeres provide well studied paradigms of heterochromatin …

Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved
in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between …

Heterochromatin maintenance is crucial for the clonal inheritance of cell identity, to ensure
the proper segregation of chromosomes and the regulation of gene expression. Although it …