In this review we summarize the present state of knowledge of the currently identified
members of the glucose transporter family, propose a basis for their diversity highlighting …

Glucose uptake into pancreatic β cells by means of the glucose transporter GLUT-2, which
has a high Michaelis constant, is essential for the normal insulin secretory response to …

The underlying cause of type 1 diabetes, loss of β-cell function, has become the therapeutic
target for a number of interventions in patients with type 1 diabetes. Even though insulin …

In mice, diabetes can be induced by multiple low doses of streptozotocin (MLD-STZ), ie, 40
mg/kg body wt on each of 5 consecutive days. In this model, diabetes develops only when …

In early 1988, a colony of GK rats was started in Paris with progenitors issued from F35 of
the original colony reported by Goto and Kakisaki. When studied longitudinally up to 8 mo …

Coordinated pulses of electrical activity and insulin secretion are a hallmark of the islet of
Langerhans. These coordinated behaviors are lost when β cells are dissociated, which also …

Amylin, a peptide copackaged with insulin in beta-cell granules, was measured in the
effluent of the perfused rat pancreases by means of a newly developed specific …

The roles of insulin resistance and beta-cell dysfunction in glucocorticoid-induced diabetes
were determined in Wistar and Zucker (fa/fa) rats. All Wistar rats treated with 5 mg/kg per d of …

To determine whether loss of beta-cell mass and function in the NOD mouse occurs
gradually, beginning after the onset of insulitis, or abruptly, just before the onset of overt …

Glucose-induced insulin secretion by beta cells of diabetic db/db mice was studied by a
pancreas perfusion technique, and the levels of GLUT2 protein in pancreatic islets were …