The roles of lipids in SARS-CoV-2 viral replication and the host immune response
The significant morbidity and mortality associated with severe acute respiratory syndrome
coronavirus 2 infection has underscored the need for novel antiviral strategies. Lipids play …
coronavirus 2 infection has underscored the need for novel antiviral strategies. Lipids play …
[HTML][HTML] Omics-driven systems interrogation of metabolic dysregulation in COVID-19 pathogenesis
Summary The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented
threat to global public health. Herein, we utilized a combination of targeted and untargeted …
threat to global public health. Herein, we utilized a combination of targeted and untargeted …
Pathways to severe COVID‐19 for people with obesity
RW O'rourke, CN Lumeng - Obesity, 2021 - Wiley Online Library
Increased morbidity and mortality from coronavirus disease 2019 (COVID‐19) in people with
obesity have illuminated the intersection of obesity with impaired responses to infections …
obesity have illuminated the intersection of obesity with impaired responses to infections …
Metabolomic analyses reveal new stage-specific features of COVID-19
H Jia, C Liu, D Li, Q Huang, D Liu… - European …, 2022 - Eur Respiratory Soc
The current pandemic of coronavirus disease 2019 (COVID-19) has affected> 160 million
individuals to date, and has caused millions of deaths worldwide, at least in part due to the …
individuals to date, and has caused millions of deaths worldwide, at least in part due to the …
Covid-19 automated diagnosis and risk assessment through metabolomics and machine learning
COVID-19 is still placing a heavy health and financial burden worldwide. Impairment in
patient screening and risk management plays a fundamental role on how governments and …
patient screening and risk management plays a fundamental role on how governments and …
Multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS
R Batra, W Whalen, S Alvarez-Mulett… - PLoS …, 2022 - journals.plos.org
Background Acute respiratory distress syndrome (ARDS), a life-threatening condition
characterized by hypoxemia and poor lung compliance, is associated with high mortality …
characterized by hypoxemia and poor lung compliance, is associated with high mortality …
Diagnostic potential of the plasma lipidome in infectious disease: application to acute SARS-CoV-2 infection
Improved methods are required for investigating the systemic metabolic effects of SARS-
CoV-2 infection and patient stratification for precision treatment. We aimed to develop an …
CoV-2 infection and patient stratification for precision treatment. We aimed to develop an …
Development and application of multidimensional lipid libraries to investigate lipidomic dysregulation related to smoke inhalation injury severity
The implication of lipid dysregulation in diseases, toxic exposure outcomes, and
inflammation has brought great interest to lipidomic studies. However, lipids have proven to …
inflammation has brought great interest to lipidomic studies. However, lipids have proven to …
Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS
Using latent class analysis (LCA) of clinical and protein biomarkers, researchers have
identified two phenotypes of the acute respiratory distress syndrome (ARDS) with divergent …
identified two phenotypes of the acute respiratory distress syndrome (ARDS) with divergent …
Metabolomic profiling of plasma reveals differential disease severity markers in COVID-19 patients
LB Oliveira, VI Mwangi, MA Sartim, J Delafiori… - Frontiers in …, 2022 - frontiersin.org
The severity, disabilities, and lethality caused by the coronavirus 2019 (COVID-19) disease
have dumbfounded the entire world on an unprecedented scale. The multifactorial aspect of …
have dumbfounded the entire world on an unprecedented scale. The multifactorial aspect of …