The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

Alternative splicing was discovered simultaneously with splicing over three decades ago.
Since then, an enormous body of evidence has demonstrated the prevalence of alternative …

Alternative splicing of pre-mRNA increases genetic diversity, and recent studies estimate
that most human multiexon genes are alternatively spliced. If this process is not highly …

Efficient targeted control of splicing is a major goal of functional genomics and therapeutic
applications. Guide (g) RNA-directed, deactivated (d) Cas CRISPR enzymes fused to …

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CFTR
gene. The 3272–26A> G and 3849+ 10kbC> T CFTR mutations alter the correct splicing of …

Splicing of pre‐messenger RNA into mature messenger RNA is an essential step for the
expression of most genes in higher eukaryotes. Defects in this process typically affect …

Removal of introns from pre‐mRNA precursors (pre‐mRNA splicing) is a necessary step for
the expression of most genes in multicellular organisms, and alternative patterns of intron …

Reduced expression of SMN protein causes spinal muscular atrophy (SMA), a
neurodegenerative disorder leading to motor neuron dysfunction and loss. However, the …

SRSF1 protein and U1 snRNPs are closely connected splicing factors. They both stimulate
exon inclusion, SRSF1 by binding to exonic splicing enhancer sequences (ESEs) and U1 …

Cystic fibrosis (CF), is an autosomal recessive disease affecting different organs. The lung
disease, characterized by recurrent and chronic bacterial infection and inflammation since …