The glycome describes the complete repertoire of glycoconjugates composed of
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …

Background Sjögren's syndrome is one of the more common inflammatory rheumatological
diseases, with a prevalence of at least 0.4% in Germany. Methods This review is based on …

Glycosylation-mediated post-translational modification is critical for regulating many
fundamental processes like cell division, differentiation, immune response, and cell-to-cell …

Circulating CD11c+ B cells are a key phenomenon in certain types of autoimmunity but have
also been described in the context of regular immune responses (ie, infections, vaccination) …

The interferon pathway, a key antiviral defense mechanism, is being considered as a
therapeutic target in COVID‐19. Both, substitution of interferon and JAK/STAT inhibition to …

Background Type I interferons (IFN-I) contribute to a broad range of rheumatic and
musculoskeletal diseases (RMDs). Compelling evidence suggests that the measurement of …

Autoimmune rheumatic diseases pose many problems that have, in general, already been
solved in the field of cancer. The heterogeneity of each disease, the clinical similarities and …

SS is usually described as having severe fatigue, dryness, diffuse pain, glandular swelling,
and various extraglandular (systemic) manifestations. Clinical trials have generally failed …

Objectives To systematically review the literature for assay methods that aim to evaluate type
I interferon (IFN-I) pathway activation and to harmonise-related terminology. Methods Three …

Type I interferons (IFN) have long been recognised as mediators of innate immune defense
mechanisms against viral threats. Robust evidence over the last 15 years revealed their …