Endometriosis-associated cancers include clear cell and endometrioid ovarian carcinoma. A
history of endometriosis has long been considered to be a risk factor for later development of …

In the past decade, there has been an increasing interest in applying proteomics to assist in
understanding the pathogenesis of ovarian cancer, elucidating the mechanism of drug …

Purpose Patient-derived tumor xenografts (PDXs) can provide more reliable information
about tumor biology than cell line models. We developed PDXs for epithelial ovarian cancer …

The majority of the targeted therapeutic agents in clinical use target proteins and protein
function. Although DNA and RNA analyses have been used extensively to identify novel …

Background It has long been appreciated that different subtypes (serous, clear cell,
endometrioid and mucinous) of epithelial ovarian carcinoma (EOC) have distinct …

Few cell line models of epithelial ovarian cancer (EOC) have been developed for the high-
grade serous (HGS) subtype, which is the most common and lethal form of gynaecological …

Aiming at clinical studies of human diseases, antibody-assisted assays have been applied
to biomarker discovery and toward a streamlined translation from patient profiling to assays …

The combretastatins (cis-stilbenoid molecules) have received significant interest because of
their simple chemical structures, excellent antiproliferative activity, and novel anti-tubulin …

The complexity and heterogeneity of ovarian cancer cases are difficult to reproduce in in
vitro studies, which cannot adequately elucidate the molecular events involved in tumor …

Estrogen receptor (ER) positive tumors represent the majority of breast malignancies, and
are effectively treated with hormonal therapies, such as tamoxifen. However, in the recurrent …