Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human
exposome. However, DNT data from animal studies are available for only a small …

Per-and polyfluoroalkyl substances (PFAS) are a diverse set of commercial chemicals
widely detected in humans and the environment. However, only a limited number of PFAS …

There is a need to assess compounds reliably and quickly for neurotoxicity (NT) and
developmental neurotoxicity (DNT). Adverse outcome pathways (AOPs) enable the mapping …

Introduction: The US Environmental Protection Agency Toxicity Forecaster (ToxCast)
program makes in vitro medium-and high-throughput screening assay data publicly …

Quantitative risk assessments of chemicals are routinely performed using in vivo data from
rodents; however, there is growing recognition that non‐animal approaches can be human …

With the abundance of chemicals in the environment that could potentially cause
neurodevelopmental deficits, there is a need for rapid testing and chemical screening …

Few models allow the study of neurite damage in the human central nervous system. We
used here dopaminergic LUHMES neurons to establish a culture system that allows for (i) …

Human induced pluripotent stem cell (hiPSC)-derived neural stem cells (NSCs) and their
differentiated neuronal/glial derivatives have been recently considered suitable to assess in …

Mycotoxins and their metabolites are a family of compounds that contains a great diversity of
both structure and biological properties. Information on their toxicity is spread within several …

Proper brain development is based on the orchestration of key neurodevelopmental
processes, including the formation and function of neural networks. If at least one key …