The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the United
States (US). Animal models, specifically mouse models have been developed to better …

There is a demand for noninvasive methods to ameliorate disease. We investigated whether
40-Hz flickering light entrains gamma oscillations and suppresses amyloid-β in the brains of …

Astrocytes provide key neuronal support, and their phenotypic transformation is implicated in
neurodegenerative diseases. Metabolically, astrocytes possess low mitochondrial oxidative …

Triggering receptor expressed on myeloid cells 2 (TREM2) plays crucial roles in Alzheimer's
disease (AD) by regulating microglia migration toward, and phagocytosis of oligomeric …

Animal models of disease are valuable resources for investigating pathogenic mechanisms
and potential therapeutic interventions. However, for complex disorders such as Alzheimer's …

The study of Alzheimer's Disease (AD) has traditionally focused on neuropathological
mechanisms that has guided therapies that attenuate neuropathological features. A new …

Brain insulin signaling controls peripheral energy metabolism and plays a key role in the
regulation of mood and cognition. Epidemiological studies have indicated a strong …

The transformation of astrocytes into reactive states constitutes a biological response of the
central nervous system under a variety of pathological insults. Astrocytes display diverse …

Recent reports implicate gut microbiome dysbiosis in the onset and progression of
Alzheimer's disease (AD), yet studies involving model animals overwhelmingly omit the …