Retinitis Pigmentosa (RP) in the human is a progressive, currently irreversible neural
degenerative disease usually caused by gene defects that disrupt the function or …

Retinal prostheses are designed to restore a basic sense of sight to people with profound
vision loss. They require a relatively intact posterior visual pathway (optic nerve, lateral …

Müller glial cells span the entire thickness of the tissue, and ensheath all retinal neurons, in
vertebrate retinae of all species. This morphological relationship is reflected by a multitude …

Mammalian retinal degenerations initiated by gene defects in rods, cones or the retinal
pigmented epithelium (RPE) often trigger loss of the sensory retina, effectively leaving the …

Transgenic mice provide a new approach for studying the structure and function of the
mammalian retina. In the past, the cellular organization of the mammalian retina was …

Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. It
has long been assumed that the surviving neural retina is largely resistant to this sensory …

Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss
of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic …

In addition to photoreceptors and neurons, glial cells (in particular Müller cells) contribute to
the removal and metabolization of neurotransmitters in the neural retina. This review …

Retinal photoreceptor degeneration takes many forms. Mutations in rhodopsin genes or
disorders of the retinal pigment epithelium, defects in the adenosine triphosphate binding …

[Frontiers in Bioscience 6, e77-92, October 1, 2001] 77 ROLE OF MÜLLER CELLS IN RETINAL
DEGENERATIONS Andreas Bringmann and And Page 1 [Frontiers in Bioscience 6, e77-92 …