The growing incidence of melanoma is a serious public health issue that merits a thorough
understanding of potential causative risk factors, which includes exposure to ultraviolet …

Interactions between the decatenation checkpoint and Topoisomerase II (TopoII) are vital for
maintaining integrity of the genome. Agents that target this enzyme have been in clinical use …

DNA Topoisomerase IIA (Topo IIA) is an enzyme that alters the topological state of DNA and
is essential for the separation of replicated sister chromatids and the integrity of cell division …

Introduction BRCA1 and BRCA2 are the two main genes causing hereditary breast and
ovarian cancer (HBOC). However, thanks to the development of Next Generation …

CHEK2 mutations have been linked with an increased risk of breast cancer. A unique
challenge for oncodermatologists and oncologists is in the monitoring and counselling of …

Defective DNA repair is being demonstrated to be a useful target in cancer treatment.
Currently, defective repair is identified by specific gene mutations, however defective repair …

The activity and efficacy of Aurora inhibitors have been reported in a wide range of cancer
types. The most prominent Aurora inhibitor is alisertib, an investigational Aurora inhibitor that …

The advent of targeted therapies of metastatic melanoma, such as MAPK pathway inhibitors
and immune checkpoint antagonists, has turned dermato‐oncology from the “bad guy” to the …

Mucosal melanoma is a rare form of melanoma which arises from melanocytes in the
mucosal membranes and can be effectively treated with immune checkpoint blockade (ICB) …

Aneuploidy, the state of the cell in which the number of whole chromosomes or chromosome
arms becomes imbalanced, has been recognized as playing a pivotal role in tumor evolution …