Live bacterial vaccine vectors: an overview

AJ Silva, TC Zangirolami, MTM Novo-Mansur… - Brazilian Journal of …, 2014 - SciELO Brasil
Genetically attenuated microorganisms, pathogens, and some commensal bacteria can be
engineered to deliver recombinant heterologous antigens to stimulate the host immune …

Live-attenuated Yersinia pestis vaccines

X Wang, X Zhang, D Zhou, R Yang - Expert review of vaccines, 2013 - Taylor & Francis
Plague caused by Yersinia pestis is one of the most dangerous infectious diseases. There is
no ideal plague vaccine available for human use, but a number of licensed killed whole-cell …

Crp Induces Switching of the CsrB and CsrC RNAs in Yersinia pseudotuberculosis and Links Nutritional Status to Virulence

AK Heroven, M Sest, F Pisano… - Frontiers in cellular …, 2012 - frontiersin.org
Colonization of the intestinal tract and dissemination into deeper tissues by the enteric
pathogen Yersinia pseudotuberculosis demands expression of a special set of virulence …

Regulatory effects of cAMP receptor protein (CRP) on porin genes and its own gene in Yersinia pestis

H Gao, Y Zhang, L Yang, X Liu, Z Guo, Y Tan, Y Han… - BMC microbiology, 2011 - Springer
Background The cAMP receptor protein (CRP) is a global bacterial regulator that controls
many target genes. The CRP-cAMP complex regulates the ompR-envZ operon in E. coli …

Progress on plague vaccine development

JA Rosenzweig, O Jejelowo, J Sha, TE Erova… - Applied microbiology …, 2011 - Springer
Yersinia pestis (YP), the gram-negative plague bacterium, has shaped human history unlike
any other pathogen known to mankind. YP (transmitted by the bite of an infected flea) …

A live attenuated strain of Yersinia pestis KIM as a vaccine against plague

W Sun, D Six, X Kuang, KL Roland, CRH Raetz… - Vaccine, 2011 - Elsevier
Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y.
pestis evades the innate immune system by synthesizing tetra-acylated lipid A with poor Toll …

Developing live vaccines against plague

W Sun, KL Roland, R Curtiss III - The Journal of Infection in Developing …, 2011 - jidc.org
Three great plague pandemics caused by the gram-negative bacterium Yersinia pestis have
killed nearly 200 million people and it has been linked to biowarfare in the past. Plague is …

Posttranscriptional regulation of the Yersinia pestis cyclic AMP receptor protein Crp and impact on virulence

WW Lathem, JA Schroeder, LE Bellows, JT Ritzert… - MBio, 2014 - Am Soc Microbiol
The cyclic AMP receptor protein (Crp) is a transcriptional regulator that controls the
expression of numerous bacterial genes, usually in response to environmental conditions …

Peeling back the many layers of competitive exclusion

JJ Maurer, Y Cheng, A Pedroso… - Frontiers in …, 2024 - frontiersin.org
Baby chicks administered a fecal transplant from adult chickens are resistant to Salmonella
colonization by competitive exclusion. A two-pronged approach was used to investigate the …

Plague vaccines: status and future

W Sun - Yersinia pestis: Retrospective and Perspective, 2016 - Springer
Three major plague pandemics caused by the gram-negative bacterium Yersinia pestis
have killed nearly 200 million people in human history. Due to its extreme virulence and the …