[HTML][HTML] Treatment of giardiasis: current status and future directions

RR Watkins, L Eckmann - Current infectious disease reports, 2014 - Springer
Giardiasis is a common yet neglected cause of diarrheal illness worldwide. Antimicrobial
therapy is usually but not always effective and drug resistance has become an increasing …

Recent advances in the development of triose phosphate isomerase inhibitors as antiprotozoal agents

LK Vázquez-Jiménez, A Moreno-Herrera… - Current Medicinal …, 2022 - ingentaconnect.com
Background: Parasitic diseases caused by protozoa, such as Chagas disease,
leishmaniasis, malaria, African trypanosomiasis, amoebiasis, trichomoniasis, and giardiasis …

[HTML][HTML] On the molecular and cellular effects of omeprazole to further support its effectiveness as an antigiardial drug

G López-Velázquez, C Fernández-Lainez… - Scientific reports, 2019 - nature.com
Research on Giardia lamblia has accumulated large information about its molecular cell
biology and infection biology. However, giardiasis is still one of the commonest parasitic …

[HTML][HTML] Disulfiram as a novel inactivator of Giardia lamblia triosephosphate isomerase with antigiardial potential

A Castillo-Villanueva, Y Rufino-González… - International Journal for …, 2017 - Elsevier
Giardiasis, the infestation of the intestinal tract by Giardia lamblia, is one of the most
prevalent parasitosis worldwide. Even though effective therapies exist for it, the problems …

Triosephosphate Isomerase Is Dispensable In Vitro yet Essential for Mycobacterium tuberculosis To Establish Infection

C Trujillo, A Blumenthal, J Marrero, KY Rhee… - MBio, 2014 - Am Soc Microbiol
Triosephosphate isomerase (TPI) catalyzes the interconversion of dihydroxyacetone
phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P). This reaction is required for …

Giardial triosephosphate isomerase as possible target of the cytotoxic effect of omeprazole in Giardia lamblia

H Reyes-Vivas, I de la Mora-de la Mora… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Giardiasis is highly prevalent in the developing world, and treatment failures with the
standard drugs are common. This work deals with the proposal of omeprazole as a novel …

Proton pump inhibitors drastically modify triosephosphate isomerase from Giardia lamblia at functional and structural levels, providing molecular leads in the design of …

I García-Torres, J Marcial-Quino… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Abstract Background Proton pump inhibitors (PPIs) are extensively used in clinical practice
because of their effectiveness and safety. Omeprazole is one of the best-selling drugs …

A guide to the effects of a large portion of the residues of triosephosphate isomerase on catalysis, stability, druggability, and human disease

V Olivares‐Illana, H Riveros‐Rosas… - Proteins: Structure …, 2017 - Wiley Online Library
Triosephosphate isomerase (TIM) is a ubiquitous enzyme, which appeared early in
evolution. TIM is responsible for obtaining net ATP from glycolysis and producing an extra …

[HTML][HTML] Structural Basis for Redox Regulation of Cytoplasmic and Chloroplastic Triosephosphate Isomerases from Arabidopsis thaliana

LM López-Castillo, P Jiménez-Sandoval… - Frontiers in plant …, 2016 - frontiersin.org
In plants triosephosphate isomerase (TPI) interconverts glyceraldehyde 3-phosphate (G3P)
and dihydroxyacetone phosphate (DHAP) during glycolysis, gluconeogenesis, and the …

[HTML][HTML] Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency

BP Roland, CG Amrich, CJ Kammerer… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Triosephosphate isomerase (TPI) is a glycolytic enzyme which homodimerizes for full
catalytic activity. Mutations of the TPI gene elicit a disease known as TPI Deficiency, a …